Synthetic Route of 766-46-1, These common heterocyclic compound, 766-46-1, name is 2′-Bromophenylacetylene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: An oven dried 20 mL glass vial was charged with PdCl2(PPh3)2 (28.1 mg, 0.04 mmol), CuI (7.6 mg, 0.04 mmol), acid chloride (2.60 mmol), terminal alkyne (2.00 mmol) and anhydrous triethylamine (10 mL). The vial was flushed with nitrogen and sealed with a pressure relief cap. The reaction mixture was stirred at room temperature, overnight, until the disappearance of starting material was observed, as monitored by thin layer chromatography. The reaction mixture was diluted with diethyl ether (40 mL) and washed with brine (40 mL). The aqueous phase was then extracted with diethyl ether (2 x 20 mL). The combined organic layers were dried over anhydrous MgSO4, and concentrated using a rotary evaporator under reduced pressure (20 mmHg). The resulting residue was purified by flash column chromatography on silica gel (eluent: hexanes/ethyl acetate).
The synthetic route of 766-46-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liu, Xiaochen; Hong, Dongsub; She, Zhigang; Hersh, William H.; Yoo, Barney; Chen, Yu; Tetrahedron; vol. 74; 45; (2018); p. 6593 – 6606;,
Bromide – Wikipedia,
bromide – Wiktionary