Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 74586-53-1, name is 3-Bromo-5-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H8BrN
To a solution of 3-bromo-5-nitrotoluene (1500g) in glacial acetic acid (11 I) in a nitrogen purged hydrogenation vessel was added 5% platinum on carbon (approx 50% water wet paste) and the mixture was hydrogenated under 4 bar hydrogen pressure at room temperature. On completion of hydrogen uptake the catalyst was removed by filtration and the filtrate split into two equal portions. Each portion was set to stir separately and a solution of potassium cyanate (500g) in water (1.25 I) was added to each over 15 min. After stirring for an additional 15 min water (10 I) was added and the precipitated solid isolated by filtration and washed with water. The water wet cakes were combined and dissolved in hot EtOAc (3 I) and the aqueous phase separated. The organic phase was cooled with stirring to crystallise the product, which was isolated by filtration and washed with fresh EtOAc (2 I) and air dried overnight. Recrystallisation from ETOH (2. 7 I) afforded the title compound. (565G) LC RT=3.9 mins.
According to the analysis of related databases, 74586-53-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; WO2004/39766; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary