Electric Literature of 7073-94-1,Some common heterocyclic compound, 7073-94-1, name is 1-Bromo-2-isopropylbenzene, molecular formula is C9H11Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The bromobenzene (1 equiv) and (3-formylphenyl)boronic acid (1 equiv) were dissolved in a mixture of 1M sodium carbonate solution (15 mL), EtOH (5 mL) and toluene 15 mL). After nitrogen substitution, Pd(PPh3)4 (0.05 equiv) wasadded. The reaction mixture was stirred at 80 C under nitrogen atmosphere for 12 h. The reaction mixture was cooled, and wate r(15 mL) was added. The mixture was diluted with ethyl acetate(15 mL), and the insoluble material was filtered off through Celite. The organic layer of the filtrate was washed with brine, dried over anhydrous sodium sulfate, and concentrated in vacuo. The residue was purified by column chromatography using a mixture of petroleum ether/ethyl acetate (10:1, v/v) as eluent to afford the desired product as a solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2-isopropylbenzene, its application will become more common.
Reference:
Article; Li; Liu, Chunxia; Yang, Jianyong; Zhou; Ye, Zhiwen; Feng; Yue, Na; Tong; Huang, Wenlong; Qian, Hai; European Journal of Medicinal Chemistry; vol. 179; (2019); p. 608 – 622;,
Bromide – Wikipedia,
bromide – Wiktionary