Synthetic Route of 698-00-0, A common heterocyclic compound, 698-00-0, name is 2-Bromo-N,N-dimethylaniline, molecular formula is C8H10BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: TMSCN (0.15 mL, 1.0 mmol) was added to a stirred mixture of PIFA (430 mg,1.0 mmol) and 3.0 mL of DCE at room temperature. After 40 min, Na2SO4(36 mg, 0.25 mmol) and tertiary amine (0.5 mmol) were then added to themixture successively and reacted for overnight. Subsequently,the mixture was poured into aqueous NaHCO3 solution and Na2S2O3solution and extracted with dichloromethane. The organic layer was washedwith brine, dried over sodium sulfate and concentrated in vacuo. Purificationby column chromatography on silica gel produced alpha-aminonitriles.
The synthetic route of 698-00-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Shen, Hang; Zhang, Xiaohui; Liu, Qing; Pan, Jing; Hu, Wen; Xiong, Yan; Zhu, Xiangming; Tetrahedron Letters; vol. 56; 41; (2015); p. 5628 – 5631;,
Bromide – Wikipedia,
bromide – Wiktionary