Adding a certain compound to certain chemical reactions, such as: 69038-76-2, name is 4-Bromo-N1-methylbenzene-1,2-diamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 69038-76-2, Quality Control of 4-Bromo-N1-methylbenzene-1,2-diamine
A mixture of 4-bromo-N1-methylbenzene-1,2-diamine (19) (250 mg, 1.2434 mmol, 1 equiv) and bisulfite adduct of benzaldehyde (392 mg, 1.8651 mmol, 1.5 equiv) in 4 mL DMF was stirred at 60?C for 4h. The reaction mixture was diluted with water and extracted with EA. The organic layer was dried, filtered and evaporated. The crude 20a (236.8 mg, 66.3% yield) was used in the next step without purification. Mp 147.6-149.9 C (150-152 C [13]). HRMS m/z calculated for C14H11N2Br [M+H]+ 287.0184, found: 287.0190. CAS No. 760212-73-5
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-N1-methylbenzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Cal??kan, Burcu; Banoglu, Erden; Guer Maz, Tu?ce; Nocentini, Alessio; Supuran, Claudiu T.; Uslu, Azize Gizem; Bioorganic Chemistry; vol. 95; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary