Application of 55289-36-6,Some common heterocyclic compound, 55289-36-6, name is 3-Bromo-2-methylaniline, molecular formula is C7H8BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 3-Bromo-2-methyl-phenylamine (15.6 g, 0.084 mol), NH2OH*H2SO4 (71.25 g, 0.5 mol), conc. HCl (8.8 mL) in H2O (90 mL) is slowly added to a solution of chloral hydrate (15.2 g, 0.09 mol), Na2SO4 (71.25 g, 0.44 mol) in H2O (255 mL) then stirred at 35 C. for 1 h, 52 C. for 1.5 h, 75 C. for 1 h. After the reaction, the mixture is filtered and the solid is dried under vacuum to give product. Yield: 18 g (83%)
The synthetic route of 55289-36-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Boehringer Ingelheim International GmbH; ENGELHARDT, Harald; GIANNI, Davide; MANTOULIDIS, Andreas; SMETHURST, Christian; US2014/296229; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary