In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 944718-31-4 as follows. Recommanded Product: 944718-31-4
5-bromo-1-methyl-1H-benzo[d][1,2,3]triazole (302.3 mg, 1.426 mmol),Benzophenone imine (342.5 mg, 1.890 mmol),t-BuONa (274.2 mg, 2.853 mmol),BINAP (87.8mg, 0.141mmol)And Pd2 (dba) 3 (131.4 mg, 0.1435 mmol)Dissolved in 1,4-dioxane (10 mL).The reaction mixture is at 100 ° C,Stir for 6 hours in a nitrogen atmosphere.After the reaction was completed, it was concentrated under reduced pressure.The residue was diluted with water (50 mL).The resulting mixture was taken with DCM and MeOHThe mixed solvent (10/1 (v/v), 80 mL × 3) was extracted.The combined organic phases were dried over anhydrous Na 2 SO 4 and filtered.The filtrate was concentrated under reduced vacuo afforded title crystallThe crude product was used directly in the next step without further purification.
According to the analysis of related databases, 944718-31-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Peng Ju; Li Xiaobo; Zhang Tao; Hu Haiyang; Chen Wuhong; Bai Changlin; Ke Donghua; Chen Peng; (217 pag.)CN109776522; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary