Synthetic Route of 40161-54-4, The chemical industry reduces the impact on the environment during synthesis 40161-54-4, name is 1-Bromo-2-fluoro-4-(trifluoromethyl)benzene, I believe this compound will play a more active role in future production and life.
To a mixture of l-bromo-2-fluoro-4-(trifluoromethyl)benzene (5.0 g, 0.02 mol) in EtOH (10 mL) was added Pd(dppf)Ci2 (1.46 g, 0.2 mmol ) and AcONa (3.37 g, 0.041 mol), and the resulting mixture was stirred at 80 C under an atmosphere of CO (50 psi) for 8 hours. The mixture was then filtrated and the filtrate was partitioned with ethyl acetate and water. The aqueous layer was separated and extracted with ethyl acetate twice. The combined organic layers were washed with brine, dried over anhydrous Na2S04 and concentrated in vacuo. The resulting residue was purified by column chromatography on silica gel (eluting with PE_EA=10: 1) to give the title compound. NMR (400MHz, CDC13) & 8.04-8.08 (t, 1H, J= 7.6 Hz), 7.49-7.47 (d, 1H, J = 8.0 Hz), 7.43-7.40 (d, 1H, J= 10.4 Hz), 4.44-4.40 (q, 2H, J= 7.2 Hz), 1.43-1.38 (t, 3H, J= 7.2 Hz).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-fluoro-4-(trifluoromethyl)benzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BIFTU, Tesfaye; COLLETTI, Steven L.; HAGMANN, William K.; KAR, Nam Fung; JOSIEN, Hubert; NAIR, Anilkumar; NARGUND, Ravi; BIJU, Purakkattle; ZHU, Cheng; HU, Bin; WO2015/51496; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary