Electric Literature of 2695-48-9,Some common heterocyclic compound, 2695-48-9, name is 8-Bromo-1-octene, molecular formula is C8H15Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of cuprous chloride (0.33 mmol) in Et2O (7 mL) at -78 C. was added a 2.0M solution BnMgBr in THF (13.1 mmol) followed by an alkyl bromide (6.52 mmol) and let warm to r.t. After reacting at r.t. for 20 hours, the reaction was cooled to 0 C. and quenched with 1 n HCl. The mixture was then extracted into three 200 mL portions ethyl acetate, dried with Na2SO4, and concentrated to a black oil. The title product was recovered after purification by flash chromatography. General procedure L was used to convert 5.98 mmol of 8-bromo-1-octene to 5.08 mmol (85%) of the title compound.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 8-Bromo-1-octene, its application will become more common.
Reference:
Patent; University of Virginia Patent Foundation; US2012/214858; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary