Electric Literature of 49764-63-8, A common heterocyclic compound, 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, molecular formula is C6H6Br2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 100 ml of toluene, 10 g (0.036 mol) of the compound of example 12.3, 9.65 g (0.079 mol) of phenylboronic acid, 10 g of potassium carbonate and 1 .05 g of tetrakistriphenylphosphinepalladium was heated at 70C for 5 h. Then, the reaction mixture was mixed with water. The phases were separated to give 10.7 g of a crude product which was purified by column chromatography (toluene) to give 8.1 g (79%)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BASF SE; Koeneman, Martin; Materan, Gabriele; Bagain, Plast Gerhard; Ivanovic, Sorin; St., Robert; (100 pag.)KR2016/38052; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary