Month: June 2021

Application of 402-43-7, These common heterocyclic compound, 402-43-7, name is 1-Bromo-4-(trifluoromethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 9. Preparation of l-(4-trifluoromethyl-phenyl)-piperidiii-4-ol intermediate. A mixture of 4-hydroxypiperidine (100 mg; 0.99 mmol), 4-bromo benzotrifiuoride (0.167 mL, 1.19 mmol), tris(dibenzylideneacetone)dipalladium (37 mg; 0.04 mmol) and 2-(dicyclohexylphosphino)-2-methylbiphenyl (29 mg; 0.08 mmol) is thoroughly flushed with argon and tetrahydrofuran is added (1 mL). A molar solution of bis-(trimethylsilyl)-lithium amide in tetrahydrofuran (1.9 mL, 1.90 mmol) is added and the reaction mixture is heated at 65C. After 17 hours reaction time, aq. IM hydrochloric acid (7.5 mL) is added and the mixture is stirred for 15 minutes before neutralization by addition of aq. sat. sodium hydrogencarbonate. The mixture is extracted with ethyl acetate (2 x 10 mL). The combined organic layers are dried over sodium sulfate, filtered and evaporated under reduced pressure to yield crude l-(4-trifiuoromethyl-phenyl)-piperidin-4-ol.

Statistics shows that 1-Bromo-4-(trifluoromethyl)benzene is playing an increasingly important role. we look forward to future research findings about 402-43-7.

Reference:
Patent; INTERVET INTERNATIONAL B.V.; CHASSAING, Christophe Pierre Alain; MEYER, Thorsten; WO2010/115688; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

2789-89-1, name is 1,2-Bis(4-bromophenyl)ethyne, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 1,2-Bis(4-bromophenyl)ethyne

General procedure: A 25 mL Schlenk-type tube (with a Teflon high pressure valve and side arm) was charged withcompound 1a (34.6 mg, 0.10 mmol), alkynes (0.20 mmol), Cu(OAc)2.H2O (5.0 mg, 0.025 mmol),[RuCl2(p-cymene)]2 (6.1 mg, 0.01 mmol), AgSbF6 (13.7 mg, 0.04 mmol) and THF (1 mL). Thereaction tube was evacuated and back-filled with N2 (3 times, ballon). After the reaction mixturewas stirred at 120 oC for 12 h, it was allowed to cool down to room temperature. The reactionmixture was diluted with ethyl acetate (20 mL), and then filtered through a pad of Celite. Thefiltrate was washed with brine (10 mL), dried over Na2SO4, and concentrated in vacuo. Theresidue was purified by silica gel preparative TLC to give the corresponding products

The synthetic route of 2789-89-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Pan, Shulei; Jiang, Hang; Zhang, Yu; Chen, Dushen; Zhang, Yanghui; Synlett; vol. 27; 13; (2016); p. 1997 – 2002;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 766-46-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 766-46-1, name is 2′-Bromophenylacetylene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a solution of sulfonyl azides 1 (0.6 mmol), o-bromo-phenylacetylenes 2 (0.5 mmol), aromatic amines 3 (0.55 mmol), and CuI (0.05 mmol) in DMSO (2 mL) in Schlenk tube was added TEA (0.5 mmol) slowly via a syringe. The reaction solution was stirred at room temperature under N2 for 2 h. The solution was then added to CuI (0.05 mmol), K2CO3 (1 mmol), and l-proline (0.2 mmol), and the mixture was stirred at 60 C under N2 for 4 h. The reaction mixture was partitioned between ethyl acetate and saturated aq NH4Cl, the organic layer was washed with brine, dried over Na2SO4, and concentrated in vacuo. The residue was purified by column chromatography on silica gel with petroleum ether and ethyl acetate (6:1 to 9:1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2′-Bromophenylacetylene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jin, Hongwei; Zhou, Bingwei; Wu, Zhi; Shen, Yang; Wang, Yanguang; Tetrahedron; vol. 67; 6; (2011); p. 1178 – 1182;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 626-40-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-40-4, name is 3,5-Dibromoaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Compound II (2.25 g, 10 mmol),Compound III (2.51 g, 10 mmol)And diisopropylethylamine(DIPEA,3.88 g, 30 mmol)Dissolved in 50 mL of dry xylene,And then heat up under nitrogen protectionReflux,Until the reaction is complete (usually 5 hours).The reaction mixture was carefully poured into 200 mL of ice water, stirred, extracted with 50 mL of X3CH2C12,Combined extraction phase,Washed sequentially with 1% dilute hydrochloric acid (200 mL) and brine (100 mL)Dried over anhydrous sodium sulfate. The desiccant was removed by suction filtration,The filtrate was evaporated to dryness on a rotary evaporator,Compound IV was obtained as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dibromoaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangdong Sai Bo Technology Co., Ltd.; Guo Huijun; (12 pag.)CN106831838; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 4333-56-6,Some common heterocyclic compound, 4333-56-6, name is Bromocyclopropane, molecular formula is C3H5Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of cyclopropyl bromide (4.0 mL, 50 mmol) in 120 mL of ether at ?78 C. was added dropwise a 1.7M solution of t-butyllithium in pentane (44.5 mL, 75.7 mmol). After 10 min, cooling bath was removed, stirring was continued for 1.5 h. The mixture was cooled again in a ?78 C. bath, and 3-furaldehyde (3.5 mL, 41.9 mmol) was added. Reaction was continued for 1 h, and quenched with a saturated NH4Cl aqueous solution. The aqueous mixture was extracted with CH2Cl2 (100 mL?3). The organic extracts were washed with brine, dried by Na2SO4, filtered, and concentrated in vacuo to give 5.3 g (91%) of the alcohol product as a yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Bromocyclopropane, its application will become more common.

Reference:
Patent; Schering Corporation; US2004/106794; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 944718-31-4, name is 5-Bromo-1-methyl-1H-benzo[d][1,2,3]triazole belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 5-Bromo-1-methyl-1H-benzo[d][1,2,3]triazole

A mixture of 5-bromo-l-methyl-liT-benzo[7][l,2,3]triazole (302.3 mg, 1.426 mmol), diphenylmethanimine (342.5 mg, 1.890 mmol), t-BuONa (274.2 mg, 2.853 mmol), BINAP (87.8 mg, 0.141 mmol) and Pd2(dba)3 (131.4 mg, 0.1435 mmol) in l,4-dioxane (10 mL) was heated to 100 °C and stirred for 6 hours under N2 atmosphere and concentrated in vacuo. The residue was diluted with water (50 mL) and the resulting mixture was extracted with a mixed solvent of DCM/MeOH (10/1 (v/v), 80 mLx 3). The combined organic layers were dried over anhydrous Na2S04 and concentrated in vacuo to give the title compound as a brown solid (445.4 mg), which was used directly in the next step without further purification. MS (ESI, pos.ion) m/z: 313.2 [M+H]+.

The synthetic route of 944718-31-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Minxiong; PENG, Ju; LI, Xiaobo; ZHANG, Tao; HU, Haiyang; CHEN, Wuhong; BAI, Changlin; KE, Donghua; CHEN, Peng; (281 pag.)WO2019/99311; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 327-52-6, name is 1-Bromo-2,4,5-trifluorobenzene, A new synthetic method of this compound is introduced below., category: bromides-buliding-blocks

116.05g trifluorobromobenzene and 400ml tetrahydrofuran were added to a clean flask. The resulting mixture was cooled to -10 to -5C, and then 864ml (0.7mol) methyl magnesium bromide was added thereto dropwisely. The mixture was stirred for 1 hour for use. 23.5g (S)-methyl 3-(benzyloxycarbonylamino)-4-oxo n-butyrate was dissolved in 300ml THF, and added dropwisely to the mixture mentioned above and kept at this temperature for 3 hours after completion of the addition. 400ml solution of ammonium chloride was added dropwisely. Layers were separated. The aqueous layer was extracted with tetrahydrofuran (200ml X 2). The organic layer was dried and concentrated to get 31.4g (3S)-methyl 3-(benzyloxycarbonylamino)-4-hydroxy-4-(2,4,5-trifluorophenyl) butyrate (yield: 78.5%).

The synthetic route of 327-52-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang Jiuzhou Pharmaceutical Co., Ltd.; EP2481722; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4117-09-3, name is 7-Bromo-1-heptene, A new synthetic method of this compound is introduced below., Recommanded Product: 7-Bromo-1-heptene

Take N-(1-adamantane)-3-indolecarboxamide (322 mg, 1.10 mmol)In dimethylformamide (5ml),Sodium hydride (88 mg, 2.20 mmol) was slowly added under ice-water bath.After the absence of bubbles, 7-bromo-1-heptene (244 mg, 1.30 mmol) was added.After 30 min reaction, the intermediate (7-(3-((1-adamantamine) formyl))-indolyl)heptene (187 mg, 44%) was obtained.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; East China Normal University; Shanghai Bangyao Biological Technology Co., Ltd.; Zhang Hankun; Pang Xiufeng; Liu Mingyao; Jiang Beier; Liu Zhitao; Yu Weiwei; Liang Qiuwen; (41 pag.)CN109879790; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 102169-44-8,Some common heterocyclic compound, 102169-44-8, name is 4-Bromo-5-methylbenzene-1,2-diamine, molecular formula is C7H9BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

B. 6-Bromo-1,4-diethyl-7-methyl-1,4-dihydro-quinoxaline-2,3-dione (Compound 24B); Compound 24A (160 mg) in 1 mL of diethyl oxalate was heated in microwave at 140 C. for 30 min. Reaction was then cooled to rt, diluted with hexanes and resulting dark brown solid (164 mg, 81%) was collected by filtration. Solution of above intermediate (164 mg, 1 eq.) and ethyl iodide (0.52 mL, 10 eq.) in 3 mL of anhydrous DMSO was cooled on ice and crushed into powder KOH (144 mg, 4.0 eq.) was added slowly. Reaction was stirred on ice for 1 hour and at rt for another hour. Reaction was then partitioned between CH2Cl2 and water. The organic layer was separated, dried over Na2SO4, filtered and the solvent was removed in vacuo. Crude was purified by column chromatography (40:60 hexane/EtOAc) to obtain 157 mg (78 %) of product. MS (electrospray): mass calculated for C13H15BrN2O2, 311.17; m/z found 312.2, [M+H]+.

The synthetic route of 102169-44-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Lagu, Bharat; Lebedev, Rimma; Pio, Barbara; US2007/78129; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 6911-87-1, name is 4-Bromo-N-methylaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6911-87-1, Quality Control of 4-Bromo-N-methylaniline

General procedure: To a solution of substituted N-methylaniline (1mmol) in CH2Cl2 (5mL) was added aqueous NaOH 25M (1mL) followed by tetrabutylammonium hydrogen sulfate (0.15mmol). After 5min of vigorous stirring, the substituted benzenesulfonyl chloride (1mmol) was added to the reaction mixture. The solution was stirred either for 3h or overnight at room temperature. Water was added to quench the reaction. Aqueous layer was extracted with CH2Cl2 (3×CH2Cl2). The organic layer was washed once with brine and once with water, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography using a mixture of n-hexane and ethyl acetate as solvent to afford the desired compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-N-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Perspicace, Enrico; Giorgio, Annalaura; Carotti, Angelo; Marchais-Oberwinkler, Sandrine; Hartmann, Rolf W.; European Journal of Medicinal Chemistry; vol. 69; (2013); p. 201 – 215;,
Bromide – Wikipedia,
bromide – Wiktionary