2695-48-9, name is 8-Bromo-1-octene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C8H15Br
Schlenk flask was charged with 10·2BH3 (1.05 g, 3.62 mmol) and THF (15 mL), and cooled to -78 C. Then n-BuLi (2.5 M in hexanes, 6.4 mL, 16.0 mmol) was added with stirring. After 30min, Br(CH2)6CH=CH2 (2.80 g, 14.65 mmol) [S10] was added to the pale yellow solution over10 min. After 1 h, the cooling bath was removed. After 16 h, a 31P{1H} NMR spectrum showedthe consumption of 10·2BH3, and water (10 mL) was added. The aqueous phase was extractedwith Et2O (4 × 10 mL), and the combined organic layers dried (MgSO4) and filtered. The solventswere removed by rotary evaporation and the residue chromatographed (SiO2 column, 4 cm× 30 cm, hexanes). The solvent was removed from the product containing fractions by rotaryevaporation to give 11·2BH3 (0.476 g, 0.652 mmol, 18%) as a colorless oil.
The synthetic route of 2695-48-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Fiedler, Tobias; Barbasiewicz, Micha?; Stollenz, Michael; Gladysz, John A.; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 2354 – 2365;,
Bromide – Wikipedia,
bromide – Wiktionary