In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1647-26-3, name is 1-Bromo-2-cyclohexylethane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 1-Bromo-2-cyclohexylethane
General procedure: The solution of dihydroxyacetophenone (1, 1.0equiv), anhydrous potassium carbonate (2.0equiv) and corresponding alkyl bromides (2, 1.1equiv) in acetonitrile was stirred at 70-80C for 4-5h. After evaporation of acetonitrile, the reaction mixture was diluted with dichloromethane and washed with water three times. The organic layer was dried with anhydrous sodium sulfate and evaporated under reduced pressure. The crude product was purified by column chromatography to give 3. 6.1.1.12 1-(2-(2-Cyclohexylethoxy)-6-hydroxyphenyl)ethanone (3l) Yield 50%; colorless liquid; Rf 0.63 (0.5:9.5 EA: HX); IR (KBr) 3230, 2919, 2848, 1618 cm-1; 1H NMR (CDCl3) delta 13.27 (s, 1H), 7.32 (t, J = 8.4 Hz, 1H), 6.53 (dd, J = 0.8, 8.4 Hz, 1H), 6.34 (d, J = 8.2 Hz, 1H), 4.11 (t, J = 6.4 Hz, 2H), 2.70 (s, 3H), 1.78 (q, J = 6.5 Hz, 2H), 1.60-1.74 (m, 5H), 1.55-1.49 (m, 1H), 1.05-1.20 (m, 3H), 0.93 (d, J = 9.0 Hz, 2H).
The synthetic route of 1647-26-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Venkateswararao, Eeda; Sharma, Vinay K.; Yun, Jieun; Kim, Youngsoo; Jung, Sang-Hun; Bioorganic and Medicinal Chemistry; vol. 22; 13; (2014); p. 3386 – 3392;,
Bromide – Wikipedia,
bromide – Wiktionary