Synthetic Route of 40161-54-4, These common heterocyclic compound, 40161-54-4, name is 1-Bromo-2-fluoro-4-(trifluoromethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(1) 1-[2-Fluoro-4-(trifluoromethyl)phenyl]butan-1-one To a solution of 1-bromo-2-fluoro-4-(trifluoromethyl)benzene (0.30mL, 2.1mmol) in THF (6mL) was added dropwise 1.5M butyllithium in THF (1.65 mL) at -78C. The mixture was stirred at -78C for 15 minutes, to which was added a solution of butyraldehyde (0.18 mL, 2.5 mmol) in THF (2 ml) at -78C. After stirring at -78C for 30 minutes, the mixture was treated with acetic acid (1 mL)/THF (2 mL), and then followed by water at room temperature. The organic layer was separated, and the aqueous layer was extracted with ether. The combined organic layers were washed with saturated brine. After drying over anhydrous sodium sulfate, the solvent was removed under reduced pressure to give 1-[2-fluoro-4-(trifluoromethyl)-phenyl]butanol.
Statistics shows that 1-Bromo-2-fluoro-4-(trifluoromethyl)benzene is playing an increasingly important role. we look forward to future research findings about 40161-54-4.
Reference:
Patent; Nippon Chemiphar Co., Ltd.; EP2277874; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary