656-64-4, name is 3-Bromo-4-fluoroaniline, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C6H5BrFN
The compound N-hydroxy-4-((3-methoxypropyl)amino)-1,2,5-oxadiazol-3-carbamimidinyl chloride (2.5 g, 10.64 mmol) was added to water. (14 ml) was heated to 60 C, 3-bromo-4-fluoroaniline (2.06 g, 11 mmol) was added, stirred for 10 minutes, then sodium bicarbonate (1.26 g, 15 mmol) was added at 60 C for 30 minutes until the reaction was complete. Extract with ethyl acetate, wash the organic phase with water, and wash with saturated brine.Drying the organic phase with anhydrous sodium sulfate,Concentrated under vacuumN-(3-Bromo-4-fluorophenyl)-N’-hydroxy-4-3-methoxypropyl)amino)-1,2,5-oxadiazole-3-carboximidamide 6e (3.9 g, 94.0%)
The synthetic route of 656-64-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jiangsu Hansoh Pharmaceutical Group Co., LTD (CN); Shanghai Hansoh Biomedical Co.,Ltd (CN); WU, SHENG HUA; GUO, FENG YING; LI, KAI LONG; HUANG, ZHI QIANG; BAO, RUDI; (94 pag.)TW2018/23219; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary