Related Products of 4333-56-6, These common heterocyclic compound, 4333-56-6, name is Bromocyclopropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred suspension of potassium fert-butoxide (8.00 g, 71.33 mmol) in DMSO (70 mL) under nitrogen was added 3-mercaptophenol (5 g, 39.63 mmol) at 0 C; the reaction was stirred at room temperature for 30 min. Then bromocyclopropane (5.72 mL, 71.33 mmol) was added into the reaction mixture. The reaction was heated at 90C overnight. After the reaction was completed, it was diluted with EtOAc. The organic layer was washed with water, saturated NH4CI aqueous solution (2x), and brine. The aqueous layer was back extracted with EtOAc (lx). The combined organic layers were dried over Na2S04, filtered and concentrated. The residue was purified by silica gel column chromatography to give the title compound (6.19 g, 85% yield). LCMS m/z = 167.2 [M+H]+; NMR (400 MHz, CDCI3) delta ppm 0.68-0.74 (m, 2H), 1.05-1.12 (m, 2H), 2.13-2.22 (m, 1H), 4.75 (s, 1H), 6.60 (dt, / = 8.08, 1.26 Hz, 1H), 6.89 (t, 7 = 2.27 Hz, 1H), 6.93 (ddd, 7 = 7.83, 1.64, 0.88 Hz, 1H), 7.15 (t, 7 = 7.96 Hz, 1H
The synthetic route of 4333-56-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; TRAN, Thuy-Anh; DO, Quyen-Quyen; ULLMAN, Brett; (259 pag.)WO2017/214002; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary