Some common heterocyclic compound, 138526-69-9, name is 1-Bromo-3,4,5-trifluorobenzene, molecular formula is C6H2BrF3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Bromo-3,4,5-trifluorobenzene
General procedure: To a mixture of 1,3,5-triazine(0.5 mmol), aryl halide (0.5 mmol), DMEDA (0.45 mmol)and K2CO3 (1 mmol) in MeCN (3 mmol) was added CuI (0.15mmol). The resulting mixture was stirred at reflux. After completionof the reaction, the reaction mixture was cooled to r.t.,concd NH3 (4 mL) and sat. NaCl (10 mL) were added, and theorganic phase was then extracted with EtOAc (3 × 15 mL). Theorganic phase was dried over anhyd Na2SO4. The crude residuewas obtained after evaporation of the solvent in vacuum, andthe residue was purified by flash chromatography with petroleumand EtOAc as the eluent to give the pure product. N2-(4-Methoxyphenyl)-N4,N4-dimethyl-6-phenyl-1,3,5-triazine-2,4-diamine (3a):
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 138526-69-9, its application will become more common.
Reference:
Article; Li, Jin Jing; Wu, Kong; Zhou, Wei; Wang, Hong; Cui, Dong-Mei; Zhang, Chen; Synlett; vol. 27; 13; (2016); p. 1993 – 1996;,
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