Synthetic Route of 2695-47-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2695-47-8, name is 6-Bromo-1-hexene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a two-neck oven-dried 250-mL round-bottom flask, 3,6-di(thiophen-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione(3.7 g, 12.2 mmol) and anhydrous K2CO3 (4.2 g, 30.5 mmol) were added. The reaction system was then evacuated and refilled with N2 before anhydrous DMF (50 mL) was injected by asyringe. After stirring and heating at 120C for 1 h, the temperatureof reaction mixture was decreased to 100C, after which6-bromohex-1-ene (5.0 g, 30.5 mmol) was added dropwise, and the reaction mixture was maintained at 100C with stirring for 2 days. After the reaction mixture was cooled to room temperature, it was poured into cold water and stirred for 30 min. The organic phase was extracted with dichloromethane, dried over anhydrous MgSO4, and then the crude product was subjected to column chromatography with hexane and chloroform as eluent. Additionally, a simple recrystallization from CHCl3/ethanol offered pure purple crystals (3.7 g, 65 %). deltaH (CDCl3, 400 MHz)8.90 (2H, d, J 3.6), 7.70 (2H, d, J 4.8), 7.31 (2H, t, J 4.8), 5.78-5.89 (2H, m), 4.49-5.04 (4H, m), 4.09 (4H, t, J 7.6), 2.09-2.15(4H, m), 1.72-1.79 (4H, m), 1.48-1.56 (6H, m).
The synthetic route of 6-Bromo-1-hexene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Shi, Zugui; Neo, Wei Teng; Zhou, Hui; Xu, Jianwei; Australian Journal of Chemistry; vol. 69; 4; (2016); p. 403 – 410;,
Bromide – Wikipedia,
bromide – Wiktionary