Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1647-26-3, name is 1-Bromo-2-cyclohexylethane, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Bromo-2-cyclohexylethane
Step 1: Preparation of ethyl 9-(2-c> elohexyIeth()xy)-6-ethyI-10-methoxy-2-oxo-6,7- dihydrobenzo [a] qiiinolizine-3-earbox late A mixture of ethyl 6-ethyl-9-hydroxy-10-methoxy-2-oxo-6,7-dihydroberizo[a]quinolizme- 3-carboxylate (50 mg, 0.15 mmol), 2 – b ro mo e t h y 1 c y c 1 o h e x a n e (57 mg, 0.3 mmol) and K2CO3 (62 mg, 0.45 mmol) in DMF (2 ml.) was stirred at 80 C for 2 hours. Water was added and the mixture was extracted with ethyl acetate. The organic phase was dried over anhydrous Na^SOj and then concentrated in vacuo to give crude ethyl 9-(2-cyclohexylethoxy)-6-ethyl- 10-methoxy- 2-0X0-6, 7-dihydrobenzo[a]qiiinolizine-3-carboxylate (69 mg) which was used in the next step without purification.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HAN, Xingchun; JAVANBAKHT, Hassan; JIANG, Min; LIANG, Chungen; WANG, Jianping; WANG, Yongguang; WANG, Zhanguo; WEIKERT, Robert James; YANG, Song; ZHOU, Chengang; WO2015/113990; (2015); A1;,
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