Adding a certain compound to certain chemical reactions, such as: 627871-16-3, name is 5-Bromo-4-fluoro-2-methylaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627871-16-3, Application In Synthesis of 5-Bromo-4-fluoro-2-methylaniline
At room temperature,The raw aniline compound (10 g, 49.0 mmol) was dissolved in 20 mL of pyridine, and the raw material was added4-nitro-2-carboxylate methylbenzenesulfonyl chloride (16.45 g, 58.8 mmol),Reaction at room temperature for more than 8 hours.After the reaction was monitored by TLC, the reaction was cooled to room temperature.Add 1N hydrochloric acid, adjust the pH to 3 ~ 4, precipitate a pale yellow precipitate, filter,Drying gave Intert I (18.6 g, yield: 84.9%). Can be used directly in the next reaction.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-4-fluoro-2-methylaniline, and friends who are interested can also refer to it.
Reference:
Patent; Shanghai Jiao Tong University School of Medicine; Zhang Jian; Zhao Mingzhu; Wei Jiacheng; (23 pag.)CN110642757; (2020); A;,
Bromide – Wikipedia,
bromide – Wiktionary