Electric Literature of 2550-36-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2550-36-9 name is (Bromomethyl)cyclohexane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[Synthesis of Compound 1]In a three-necked flask, 20 g of bromomethylcyclohexane and 12.5 g of 1-naphthol were dissolved in 300 g of NMP. Thereafter, 12 g of potassium carbonate and 14 g of potassium iodide were added to the solution, and heated at 120 C. for 8 hours. Water amounting to 300 g was added to the thus obtained reaction liquid, and was extracted with 100 g of hexane three times. The obtained organic phases were collected, and washed with 100 g of 1N aqueous sodium hydroxide solution once, with 100 g of water once and with 100 g of brine once. The thus washed organic phase was concentrated, thereby obtaining 13 g of compound 1.An NMR chart of the compound 1 is given in FIG. 1.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (Bromomethyl)cyclohexane, and friends who are interested can also refer to it.
Reference:
Patent; FUJIFILM CORPORATION; US2012/237874; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary