Application of 766-81-4,Some common heterocyclic compound, 766-81-4, name is 3-Bromophenylacetylene, molecular formula is C8H5Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under nitrogen protection, the product of step 1 and 2.5 equivalents of m-bromophenylacetylene and 0.05 equivalent of cuprous iodide in a solution of diisopropylamine and dichloromethane (volume ratio 1:10) was reacted under nitrogen atmosphere at room temperature for 24 h . The product was isolated on a silica gel column and the yield was 75-80%.
The synthetic route of 766-81-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dalian University of Technology; Ni, Jun; Gai, Xuqiao; Kang, Jiajia; Xu, Liang; (7 pag.)CN105732721; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary