Synthetic Route of 656-64-4,Some common heterocyclic compound, 656-64-4, name is 3-Bromo-4-fluoroaniline, molecular formula is C6H5BrFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 3-bromo-4-fluoroaniline (1.9 g, 10.00 mmol) and 5- (methoxymethylene)-2,2-dimethyl- 1,3 -dioxane-4,6-dione (2.234 g, 12.00 mmol) in dioxane (5 mL) was heated to 120 C for 20 minutes. The reaction mixture is then cooled to room temperature and diluted with 50 ml of dietheyl ether. The solid was filtered and dried to give 5 -(((3 -bromo-4-fluorophenyl)amino)methylene)-2,2-dimethyl- 1,3 -dioxane4,6-dione (2.77 g, 8.0 mmol, 80%). ?HNMR(400 MHz, DMSO-d6) oe 11.23 (br d, J=14.4 Hz, 1H), 8.53 (d, J=14.5 Hz, 1H), 8.06 (dd, J=6.0, 2.8 Hz, 1H), 7.69 – 7.61 (m, 1H), 7.44 (t, J=8.7 Hz, 1H), 1.73 – 1.63 (m, 6H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-4-fluoroaniline, its application will become more common.
Reference:
Patent; INNATE TUMOR IMMUNITY, INC.; O’MALLEY, Daniel; GAVAI, Ashvinikumar V.; GILL, Patrice; TARBY, Christine M.; WATTERSON, Scott Hunter; GONG, Hua; WILLIAMS, David K.; GHOSH, Shomir; ROUSH, William R.; (307 pag.)WO2019/14402; (2019); A1;,
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