Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 627871-16-3, name is 5-Bromo-4-fluoro-2-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 627871-16-3
WXBB-1-4a (20.00 g, 98.02 mmol, 1.00 eq) was dissolved in N-methylpyrrolidone (100.00 mL), followed by addition of cuprous cyanide (17.56 g, 196.04 mmol, 42.83 mL, 2.00 eq). The reaction was carried out at 180C for 3 hours. The reaction solution was cooled to room temperature, followed by addition of water (300 mL) and ammonia (300 mL), stirred at room temperature for 30 minutes, and extracted with ethyl acetate (200 mL 3). The organic phase was washed with saturated brine (200 mL) and water (200 mL), dried over anhydrous sodium sulfate, suction-filtered and rotary evaporated to dry under reduced pressure to give a crude product as a brown-black solid. The crude product was isolated by silica gel column chromatography (PE: EA=20:1-3:1) to give WXBB-1-4 (12.00 g, 79.92 mmol, 81.53% yield) as a yellow solid. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 2.21 (s, 3 H) 3.68 (br s, 2 H) 6.80 (d, J=5.40 Hz, 1 H) 6.91 (d, J=9.29 Hz, 1 H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 627871-16-3.
Reference:
Patent; Fujian Cosunter Pharmaceutical Co., Ltd.; WU, Chengde; YU, Tao; LI, Ning; CHEN, Shuhui; (58 pag.)EP3572412; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary