These common heterocyclic compound, 1137142-58-5, name is 2-Bromoimidazo[2,1-b][1,3,4]thiadiazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 1137142-58-5
Intermediate K2-Bromo-5-nitro-imidazo[2,1-b][1,3,4]thiadiazole; Fuming nitric acid (0.15 mL) was added at 0C to a solution of 2-bromo- imidazo[2,1-b][1 ,3,4]thiadiazole (0.200 g, 1 mmol) in cone, sulfuric acid (0.24 mL), and the mixture was stirred for 5h. Ice was added, and stirring was continued for 30 min. The solid was filtered off, washed with cold water and dried to give the title compound (0.244 g; 83%)1H NMR (300 MHz, DMSO) delta 8.55 (s, 1 H) ppm.
The synthetic route of 2-Bromoimidazo[2,1-b][1,3,4]thiadiazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; KURZ, Guido; RICO FERREIRA, Maria del Rosario; SOILAN RODRIGUEZ, David; ORTEGA SORET, Miguel Angel; MARTINEZ GONZALEZ, Sonia; WO2011/121317; (2011); A1;,
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