4333-56-6, name is Bromocyclopropane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 4333-56-6
Step (i) of Example W1: 4-Cyclopropylmethylpyridine A solution of 19.5 ml (200 mmol) of 4-picoline in tetrahydrofuran (120 ml) was cooled to -78C. Lithium diisopropylamide (2 M heptane, tetrahydrofuran, ethylbenzene solution) (200 ml) was added dropwise to the cooled solution over a period of 20 min. The mixture was then stirred at -40C for 20 min and was cooled to -78C. Cyclopropylbromide (16.0 ml, 200 mmol) was added dropwise to the reaction solution over a period of 25 min, and the mixture was stirred at -78C for one hr. The reaction solution was then added to 300 ml of a saturated aqueous ammonium chloride solution, and the mixture was satisfactorily washed with 100 ml of water. The solution was extracted twice with 200 ml of ethyl acetate, and the extract was dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated, and the residue was distilled under the reduced pressure (8 mmHg, 86 to 87C). The distillation residue was purified by column chromatography on silica gel (hexane : ethyl acetate = 70 : 30) to give 17.6 g (yield 66%) of the title compound. 1H-NMR (400 MHz, CDCl3) delta: 0.19-0.25 (2H, m), 0.55-0.61 (2H, m), 0.93-1.04 (1H, m), 2.54 (2H, d, J = 7.1 Hz), 7.17-7.22 (2H, m), 8.47-8.52 (2H, m). MS (FAB) m/z 134 [M+H]+.
The synthetic route of 4333-56-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Meiji Seika Kaisha Ltd.; EP2151447; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary