17247-58-4, name is (Bromomethyl)cyclobutane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C5H9Br
4-(4,455-tetramethyl-1 3,2-dioxaborolan-2-yl)-1H-pyrazole (2.00 g, 10.3 mmol), (bromomethyl)cyclobutane (3.5 ml, 31 mmol) and potassium carbonate (5.70 g, 41 .2 mmol) were stirred in N,N-dimethylacetamide (16 ml) overnight at 80C. The mixture was concentrated under reduced pressure, the residue was dissolved with ethyl acetate, and the resulting solution was washed three times with water. The combined organic layers were dried over a silicone filter and concentrated under reduced pressure to give 2.40 g (90 % purity, 80 % yield) of the title compound. LC-MS (Method 2): Rt = 1 .21 min; MS (ESIpos): m/z = 263 [M+H]+ 1H-NMR (400MHz, DMSO-d6): _ [ppm]= 1.24 (s, 12H), 1 .67 – 1 .99 (m, 6H), 2.67 – 2.77 1H), 4.12 (d, 2H), 7.55 (s, 1H), 7.90 (d, 1H).
The synthetic route of 17247-58-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; LEFRANC, Julien; MENGEL, Anne; SCHULZE, Volker; CHRIST, Clara; PRINZ, Florian; WENGNER, Antje, Margret; STOeCKIGT, Detlef; BOeMER, Ulf; BADER, Benjamin; (288 pag.)WO2017/207534; (2017); A1;,
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