Reference of 4333-56-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4333-56-6, name is Bromocyclopropane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Tert-butyl N-ftert-butoxycarbonylamino)-N-cvclopropyl-carbamate To a stirred suspension of magnesium (1.34g, 55mmol) and catalytic iodine in tetrahydrofuran (5ml)was added 5ml of a 45ml solution of cyclopropyl bromide (4.0ml) in tetrahydrofuran (50ml). The mixture was heated to initiate Grignard formation then the remaining solution of cyclopropyl bromide was added dropwise over 30mins with heating (70C). The Grignard solution was heated at reflux for a further 30 minutes then cooled to 0C. To a stirred solution of di-tert-butyl azodicarboxylate in THF (50ml) at -78C was added the solution of cyclopropylmagnesium bromide dropwise via cannula. The resulting solution was stirred at -78C for 30mins then quenched with acetic acid. The mixture was allowed to warm to room temperature then water (150 ml) was added and the mixture extracted three times with diethyl ether. The combined organic extracts were dried, filtered and concentrated in vacuo. The crude product was purified by column chromatography on silica, eluting with ethyl acetate/hexane, to give the product as a white solid (6.68g). IH NMR (400 MHz, Chloroform) delta ppm 0.7 (4H, br s), 1.5 (18H, s), 2.9-3.0 (IH, br m), 6.1 and 6.4 (IH, br s)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Bromocyclopropane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SYNGENTA LIMITED; BHONOAH, Yunas; ELLIOTT, Alison Clare; GAULIER, Steven; LING, Kenneth; MITCHELL, Glynn; MORRIS, James Alan; RZEPA, Paula Rocha; VINER, Russell Colin; WO2013/50421; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary