Electric Literature of 64248-56-2, A common heterocyclic compound, 64248-56-2, name is 2-Bromo-1,3-difluorobenzene, molecular formula is C6H3BrF2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of 2-bromo-l,3-diflurobenzene (CAS 64248-56-2, 10.0 g, 51.8 mmol) in H2SO4 (30 mL) at 0 C under nitrogen atmosphere was added HNO3 (65%, 25 mL) in dropwise. The resulting mixture was warmed to room temperature and stirred for 1 hour. After that, the reaction mixture was poured onto ice and vigorously stirred for 5 minutes. The resulting suspension was extracted with CH2CI2 (4 x 125 mL), washed with brine (200 mL), dried over Na2S04 and concentrated in vacuo to get compound XIa (crude). The obtained crude product was taken for the next step without any further purification. Yield: 9.00 g, 72.99%. -1H NMR (400 MHz, DMSO-d6): 8.34- 8.29 (m, 1H), 7.56 – 7.51 (m, 1H).
The synthetic route of 64248-56-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BUGWORKS RESEARCH INDIA PVT LTD; PEER MOHAMED, Shahul Hameed; BHARATHAM, Nagakumar; KATAGIHALLIMATH, Nainesh; SHARMA, Sreevalli; NANDISHAIAH, Radha; RAMACHANDRAN, Vasanthi; VENKATARAMAN, Balasubramanian; (221 pag.)WO2018/225097; (2018); A1;,
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