Related Products of 4333-56-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4333-56-6 name is Bromocyclopropane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Preparation of 1.1-cyclopropyl-1hydro-naphthalene [2,3-bis]imidazole-4,9-dione: Naphthyl imidazole (396 mg, 2.0 mmol) was dissolved in dimethyl sulfoxide (10 mL). Further, sodium hydride (376 mg, 6.0 mmol) was added, and the mixture was stirred at room temperature for 30 min to give a brown-yellow liquid, and then bromocyclopropane (4.8 mL, 60 mmol) was added and stirring was continued for 24 hours. The reaction solution was poured into ice water (50 g), and the pH was adjusted to 9 with dilute hydrochloric acid (1.0M). After extracting 5 times with chloroform (20 mL/time), the organic phase was washed with saturated brine and dried over anhydrous magnesium sulfate, filtered and evaporated to remove solvent.By silica gel column chromatographyThe yellow solid was 422 mg, yield 87%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Bromocyclopropane, and friends who are interested can also refer to it.
Reference:
Patent; Shanghai Jiao Tong University; Yan Deyue; Zhang Wanbin; Zhang Zhenfeng; Liu Zhanxiong; (21 pag.)CN108794403; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary