Related Products of 4333-56-6, These common heterocyclic compound, 4333-56-6, name is Bromocyclopropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a microwave vial charged with Mg powder (2 equiv.) and THF was addedbromocyclopropane (2 equiv.). The resulting mixture was stirred for 30 min at rt before a solution of arylnitrile (1 equiv.) in THF was added. It was microwaved 10 min at 100 C, cooled to rt and added dropwise to a cold solution of NaBFL, (2 equiv.) in MeO at 0 C. The resulting mixture was stirred for 15 min at rt, quenched with H20, extracted with DCM and purified by Biotage Si02 column (gradient: MeOH/DCM 0-30%) to give the desired product.
The synthetic route of 4333-56-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UNIVERSITY HEALTH NETWORK; PAULS, Heinz W.; LAUFER, Radoslaw; LIU, Yong; LI, Sze-Wan; FORREST, Bryan T.; LANG, Yunhui; PATEL, Narendra Kumar B.; EDWARDS, Louise G.; NG, Grace; SAMPSON, Peter Brent; FEHER, Miklos; AWREY, Donald E.; WO2013/53051; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary