Reference of 10546-67-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10546-67-5, name is 2,6-Dibromo-4-(tert-butyl)aniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a mixtureof 500 mL of 96 % ethanol and 133 mL of 98 % H2SO4, 26.14g (89.2 mol) of 2,6-dibromo-4-isopropylaniline (S12n) was added withvigorous stirring at -5 C over 15 min. Then, 16.864 g of NaNO2 wasadded at this temperature over 1 h, and the resulting mixture was stirred at 80C overnight. Then, ice water was added to the reaction system and the organicproduct was extracted with 4 × 400 ml of dichloromethane. The combined extractwas dried over Na2SO4 and evaporated to get compound1,3-dibromo-5-isopropylbenzene (15.7 g, 63 %).
The synthetic route of 2,6-Dibromo-4-(tert-butyl)aniline has been constantly updated, and we look forward to future research findings.
Reference:
Article; Yu, Lei; Huang, Minhao; Xu, Tianfeng; Tong, Linjiang; Yan, Xiao-e; Zhang, Zhang; Xu, Yong; Yun, Caihong; Xie, Hua; Ding, Ke; Lu, Xiaoyun; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 1107 – 1117;,
Bromide – Wikipedia,
bromide – Wiktionary