Electric Literature of 142808-15-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 142808-15-9, name is 4-Bromo-2-fluorobenzotrifluoride belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Under nitrogen atmosphere, a solution of (2R,4R)-2,4-pentanediol (2.604 g, 25.0 mmol) in anhydrous N,N-dimethylformamide (DMF, 40.0 mL) was added dropwise to a suspension of sodium hydride (2.100 g, 60% in mineral oil, 52.5 mmol) in anhydrous DMF (40.0 mL) at 0 C and the reaction was stirred at 0 C for 30 min. 4-Bromo-2-fluorobenzotrifluoride (13.36 g, 55.0 mmol) in anhydrous DMF (20.0 mL) was added at 0 C. The reaction warmed to room temperature and stirred for 30 min. Then, the reaction mixture was heated to 100 C and stirred at 100 C for 12 h. After cooling to room temperature, the reaction was quenched by addition of saturated aqueous ammonium chloride. The organic phase was separated and the water phase was extracted with diethyl ether (30.0 mLx3). The combined organic layer was washed with water and brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude material was purified by column chromatography (hexanes) to give the 1 (12.12 g, 88% yield)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2-fluorobenzotrifluoride, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Xie, Huan-Ping; Yan, Zhong; Wu, Bo; Hu, Shu-Bo; Zhou, Yong-Gui; Tetrahedron Letters; vol. 59; 31; (2018); p. 2960 – 2964;,
Bromide – Wikipedia,
bromide – Wiktionary