Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 626-40-4, name is 3,5-Dibromoaniline, A new synthetic method of this compound is introduced below., Safety of 3,5-Dibromoaniline
To a solution of 3,5-dibromoaniline (5.0 g, 19.9 mmol) in dioxane (50 ml) and H20 (5 ml) was added 2-isopropenyl-4, 4,5, 5-tetramethyl- 1,3,2- dioxaborolane (10.19 ml, 53.8 mmol) and Pd(dppf)Cl2 (729 mg, 1.00 mmol) and Cs2C03 (19.48 g, 59.8 mmol) at rt under N2. The reaction was stirred at 100 C for 12 h under N2. The solution was concentrated in vacuo and the resulting residue was poured into water (50 ml) and stirred for 0.5 h. The aqueous phase was extracted with ethyl acetate (3 x 100 ml). The combined organic phase was concentrated in vacuo. The crude product was purified by FCC (17 % EtOAc in petroleum ether) to give the title compound as a yellow oil (Y = 78 %). NMR (400 MHz, DMSCMe) d ppm 6.76 (s, 1H), 6.64 (s, 2H), 5.23 (s, 2H), 5.10 (s, 2H), 5.01 (s, 2H), 2.06 (s, 6H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; NODTHERA LIMITED; HARRISON, David; WATT, Alan Paul; BOCK, Mark G.; (334 pag.)WO2019/121691; (2019); A1;,
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