Related Products of 58971-11-2,Some common heterocyclic compound, 58971-11-2, name is 3-Bromophenethylamine, molecular formula is C8H10BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 2-(3-Bromophenyl) ethylamine (7.3 g, 36 mmol) and triethylamine(15 mL, 107 mmol) in dry dichloromethane (70 mL) is added trifluoroacetic anhydride drop- wise and the reaction mixture is stirred at room temperature for 2 h. The reaction mixture is diluted with dichloromethane, washed with water and brine, dried over sodium sulfate and concentrated. The crude product is purified by column chromatography (silica gel, 60-120 mesh) using 10% ethyl acetate in petroleum ether as eluent to obtain the product as light yellow solid (7.8 g, 72%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromophenethylamine, its application will become more common.
Reference:
Patent; NOVARTIS AG; WO2008/76954; (2008); A2;,
Bromide – Wikipedia,
bromide – Wiktionary