Related Products of 68322-84-9, These common heterocyclic compound, 68322-84-9, name is 2-Bromo-1-fluoro-4-(trifluoromethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The product from Scheme 14, Step 4 (136 mg, 0.407 mmol, 1 eq), 2-bromo-1- fluoro-4-(trifluoromethyl)benzene (148 mg, 0.61 mmol, 1.5 eq), CuI (16 mg, 0.084 mmol, 0.2 eq), and Cs2CO3 (265 mg, 0.82 mmol, 2 eq) were combined in DMF (1.5 ml_) and heated for 3h at 900C. The reaction was filtered and the filtrate was partitioned between EtOAc and water. The aqueous layer was discarded, and the organic layer was washed three times more with water, was dried over anhydrous sodium sulfate, was filtered, and was evaporated to afford a crude residue. Preparative thin layer silica gel chromatography (20cmX20cm, 1000 mum, developed with 3% EtOAc in hexanes) afforded the desired product (145 mg).
Statistics shows that 2-Bromo-1-fluoro-4-(trifluoromethyl)benzene is playing an increasingly important role. we look forward to future research findings about 68322-84-9.
Reference:
Patent; SCHERING CORPORATION; WO2009/140342; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary