Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 626-40-4, name is 3,5-Dibromoaniline, A new synthetic method of this compound is introduced below., Application In Synthesis of 3,5-Dibromoaniline
General procedure: In a nitrogen filled glove box, a 10 mL pressure tube, equippedwith a magnetic stir bar was loaded with the titanium catalyst(0.10 mmol) and dissolved in dry toluene (2 mL). The solutionwas loaded with the aniline derivative (1.0 mmol), alkyne derivative(1.0 mmol) and tert-butylisonitrile (1.5 mmol). The pressuretube was sealed with a Teflon screw cap, taken out of the dry boxand heated at 100 C for 24-48 h in a silicone oil bath. Volatileswere removed in vacuo, and glacial acetic acid (2 mL) was added.The mixture was then heated at 150 C for 24 h. The pressure tubewas then allowed to cool to room temperature, diluted in dichloromethaneand neutralized with saturated NaHCO3 solution. Theorganic layer was further extracted with additional dichloromethane,washed with brine, dried over NaSO4, filtered and concentratedin vacuo. The crude product was dry loaded onto aluminaand purification was accomplished by column chromatography on neutral alumina using hexanes/ethyl acetate (9:1, v/v) as the eluentto provide the desired quinoline.4.1.1. 5,7-Dimethyl-3-phenylquinoline (4)Pale yellow solid 128 mg (55%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; McDaniel, Tanner J.; Lansdell, Theresa A.; Dissanayake, Amila A.; Azevedo, Lauren M.; Claes, Jacob; Odom, Aaron L.; Tepe, Jetze J.; Bioorganic and Medicinal Chemistry; vol. 24; 11; (2016); p. 2441 – 2450;,
Bromide – Wikipedia,
bromide – Wiktionary