Reference of 61613-22-7, These common heterocyclic compound, 61613-22-7, name is 2-Bromo-N-phenylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
33 g (145 mmol) of di-tert-butyl dicarbonate first fill in 600 mL of toluene. To this solution 27g (110 mmol) of (2-bromophenyl)phenylamine and 1.3 g (11 mmol) of 4-dimethylaminopyridine, The mixture is boiled under reflux for 40 h. Subsequently 200mL of water was added to the reaction and separating the organic phase, the solvent was removed under reduced pressure. The residue was then recrystallized from hot hexane. Yield: 36 g (103 mmol), 95%.
Statistics shows that 2-Bromo-N-phenylaniline is playing an increasingly important role. we look forward to future research findings about 61613-22-7.
Reference:
Patent; Merck Patent GMBH; Farrahm, Amir Hossain; Flume, Christoph; Everille, Thomas; Yatsi, Anya; Montenegra, Elvira; Krober, Jonas Valentine; Rinke, Roophen; (59 pag.)KR2016/27155; (2016); A;,
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bromide – Wiktionary