Month: August 2021

Related Products of 4333-56-6, These common heterocyclic compound, 4333-56-6, name is Bromocyclopropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a microwave vial charged with Mg powder (2 equiv.) and THF was addedbromocyclopropane (2 equiv.). The resulting mixture was stirred for 30 min at rt before a solution of arylnitrile (1 equiv.) in THF was added. It was microwaved 10 min at 100 C, cooled to rt and added dropwise to a cold solution of NaBFL, (2 equiv.) in MeO at 0 C. The resulting mixture was stirred for 15 min at rt, quenched with H20, extracted with DCM and purified by Biotage Si02 column (gradient: MeOH/DCM 0-30%) to give the desired product.

The synthetic route of 4333-56-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITY HEALTH NETWORK; PAULS, Heinz W.; LAUFER, Radoslaw; LIU, Yong; LI, Sze-Wan; FORREST, Bryan T.; LANG, Yunhui; PATEL, Narendra Kumar B.; EDWARDS, Louise G.; NG, Grace; SAMPSON, Peter Brent; FEHER, Miklos; AWREY, Donald E.; WO2013/53051; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 10546-67-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10546-67-5, name is 2,6-Dibromo-4-(tert-butyl)aniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a mixtureof 500 mL of 96 % ethanol and 133 mL of 98 % H2SO4, 26.14g (89.2 mol) of 2,6-dibromo-4-isopropylaniline (S12n) was added withvigorous stirring at -5 C over 15 min. Then, 16.864 g of NaNO2 wasadded at this temperature over 1 h, and the resulting mixture was stirred at 80C overnight. Then, ice water was added to the reaction system and the organicproduct was extracted with 4 × 400 ml of dichloromethane. The combined extractwas dried over Na2SO4 and evaporated to get compound1,3-dibromo-5-isopropylbenzene (15.7 g, 63 %).

The synthetic route of 2,6-Dibromo-4-(tert-butyl)aniline has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yu, Lei; Huang, Minhao; Xu, Tianfeng; Tong, Linjiang; Yan, Xiao-e; Zhang, Zhang; Xu, Yong; Yun, Caihong; Xie, Hua; Ding, Ke; Lu, Xiaoyun; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 1107 – 1117;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4117-09-3, name is 7-Bromo-1-heptene, A new synthetic method of this compound is introduced below., Formula: C7H13Br

Magnesium chips (0.24 g, 10.1 mmol) were protected with argon.And add 5mL of dry THF to take 7-bromo-1-heptene(1.5 mL, 9.6 mmol) in a disposable syringe,First, a small amount of 7-bromo-1-heptene (about 10% by volume)Infused into the reaction solution,Then add a small amount of 1,2-dibromoethane (about 0.1mL) to initiate the reaction, and then slowly add the remaining 7-bromo-1-heptene (added in 5min)Into the reaction solution, after the addition is complete,Heated back to reflux for 30 min (about 60 C),A freshly prepared Grignard reagent of 7-bromo-1-heptene was obtained.The nitrone formula (3-1) (2 g, 4.8 mmol) was dissolved in 20 mL of dry THF, argon-protected and cooled to 0 C.The above-mentioned new Grignard reagent (5mL)Add dropwise to the reaction solution (added in 2 minutes)The reaction was stirred for 1 h. The reaction was quenched with saturated aq.Dry over anhydrous MgSO 4, filtered and evaporated.2.5 g of the crude product of the product hydroxyamine (4-1) was obtained.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Chinese Academy Of Sciences Chemical Institute; Yu Chuyi; Song Yingying; Jia Yuemei; Li Yixian; Jia Tengdun; (29 pag.)CN105085356; (2018); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 2576-47-8, A common heterocyclic compound, 2576-47-8, name is 2-Bromoethylamine hydrobromide, molecular formula is C2H7Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General Synthesis Instructions for N-Z-2-bromoethylamine/N-Z-3-bromopropylamine: Add a solution of 1.5 equivalents of benzylchloroformiate in 50 ml Rotisol in drops to a solution of one equivalent of 2-bromoethylamine-hydrobromide or 3-bromopropylamine-hydrobromide and three equivalents of triethylamine in 150 ml Rotisol under refrigeration. Stir for 20 hours at room temperature, then concentrate the formulation to a small volume, take it up in 200 ml ethyl acetate, and extract twice against 200 ml 2 N hydrochloric acid each time. Remove the solvent and purify the residue via column chromatography on 100 g silica gel. Elute the apolar impurities with cyclohexane/diisopropyl ether (10:1), and elute the product with diisopropyl ether; N-Z-2-bromoethylamine (72): Quantities Used: 34.8 g (170 mmol) 2-bromoethylamine-hydrobromide, 72.0 ml (255 mmol) 50% solution of benzylchloroformiate in toluene, 70.6 ml (510 mmol) triethylamine

The synthetic route of 2576-47-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Massing, Ulrich; Fichert, Thomas; US2003/229037; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24358-62-1 as follows. name: 1-(4-Bromophenyl)ethylamine

A solution of 4-bromo-alfa-methylbenzylamine (1 mmol) and 3,5-bis-(trifluoromethyl)phenyl isothiocyanate (1 mmol) in CHCI2 (5 mL) was stirred at r.t. for 24 h. The precipitate was collected and washed with n-heptane, giving compound C as white crystals (158 mg).

According to the analysis of related databases, 24358-62-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LICA PHARMACEUTICALS; WO2008/43840; (2008); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 108-85-0, name is Bromocyclohexane, molecular formula is C6H11Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C6H11Br

General procedure: An alkyl halide (2 mmol) and HMDS (3 mmol) were addedto a solution of thiourea (2.2 mmol) in wet DMSO (2 mLDMSO + 0.05 mL H2O). The mixture was stirred magneticallyat 50 C for 10-24 h. Then, the mixture was dilutedwith water (2 mL) and extracted with 1:1 EtOAc/hexane(3 × 2 mL). The upper layers were decanted, combined,and concentrated. The crude product was purified by silicagel chromatography using low-boiling petroleum ether aseluent to provide the desired disulfide in high yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 108-85-0, its application will become more common.

Reference:
Article; Abbasi, Mohammad; Jabbari, Arida; Journal of the Iranian Chemical Society; vol. 13; 1; (2016); p. 81 – 86;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 40161-54-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 40161-54-4, name is 1-Bromo-2-fluoro-4-(trifluoromethyl)benzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Intermediate G: 4-(2-Bromo-5-(trifluoromethyl)phenyl)morpholine A microwave vial charged with potassium phosphate (0.533 g, 2.51 mmol), 1- bromo-2-fluoro-4-(trifluoromethyl)benzene (0.610 g, 2.51 mmol) and 1 mL dioxane, was treated with morpholine (0.437 ml, 5.02 mmol) and was heated to 150C in a microwave reactor for one hour. LC/MS showed mostly starting material, so the reaction mixture was treated with 1 mL DMF and was heated to 150 C in an oil bath overnight. LC/MS showed product, so the reaction mixture was diluted with DCM, filtered through a syringe filter, and concentrated. Purification of the resulting residue by silica gel column chromatography (0 to 50% EtO Ac/heptane) gave 4-(2-bromo-5- (trifluoromethyl)phenyl)morpholine (0.280 g, 0.903 mmol) as a clear oil. [M+H]+ = 312.0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-fluoro-4-(trifluoromethyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AMGEN INC.; DINEEN, Thomas; KREIMAN, Charles; WEISS, Matthew; GEUNS-MEYER, Stephanie; WO2013/134518; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 57946-63-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57946-63-1, name is 2-Bromo-4-(trifluoromethyl)aniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a stirred solution of 2-haloaniline derivatives in DCM, Et3N (1.3 equiv.) was added and the resulting mixture was cooled to 0 °C. Stirred for 5 min and acid chloride (1.1 equiv.) was added drop wise. Stirred overnight from 0 °C to RT. The reaction mixture was extracted with DCM and washed with NaHCO3 and brine. The organic phase was dried over anhydrous sodium sulphate and the solvent was evaporated using vacuum rotary evaporator. The resulting residue was purified on silica gel column chromatography using n-hexane and ethyl acetate as eluent.

The synthetic route of 2-Bromo-4-(trifluoromethyl)aniline has been constantly updated, and we look forward to future research findings.

Reference:
Article; Venu Saranya, Thachora; Rajan Sruthi, Pambingal; Anas, Saithalavi; Synthetic Communications; vol. 49; 2; (2019); p. 297 – 307;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 7051-34-5,Some common heterocyclic compound, 7051-34-5, name is (Bromomethyl)cyclopropane, molecular formula is C4H7Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 4-fluoro-3-hydroxybenzonitrile (10.0 g, 78.74 mmol) in dry DMF (100 mL), K2C03 (21.73 g, 157.4 mmol) was added followed by addition ofcyclopropyl methyl bromide (12.85 g, 94.48 mmol). The reaction mixture was heated at 90C for 4 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was quenched with cold water and precipitated solid wasfiltered, washed with pentane to afford XII. Yield: 12 g, 94%; ?H NMR (400 MHz, CDC13) 7.28-7.11 (m, 3H), 3.90 (d, J= 7.1 Hz, 2H), 1.32-1.29 (m, 1H), 0.76-0.63 (m, 2H), 0.45-0.32 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (Bromomethyl)cyclopropane, its application will become more common.

Reference:
Patent; CV6 THERAPEUTICS (NI) LIMITED; SPYVEE, Mark; LEWIS, Michael; (300 pag.)WO2018/98204; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 18599-22-9, A common heterocyclic compound, 18599-22-9, name is 4-Bromo-3,3,4,4-tetrafluorobut-1-ene, molecular formula is C4H3BrF4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Bromo-3,3,4,4-tetrafluoro-1-butene (8.7 g, 42 mmol), anthracene (5.0 g, 28 mmol), and toluene (100 g) were put into a 300 mL pressure resistant reaction container and reacted at 150 C. for 24 hours. Subsequently, after cooling to room temperature, the resultant was concentrated using a rotary evaporator. Methanol (50 g) was added to the concentrate, followed by stirring. The precipitated solid was subjected to filtration. Then, the filtrate was dried under a reduced pressure to obtain an intermediate 4b (6.0 g, yield=55.6%).

The synthetic route of 18599-22-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TOKYO OHKA KOGYO CO., LTD.; IKEDA, Takuya; SHIOSAKI, Masahiro; ARAI, Masatoshi; KOMURO, Yoshitaka; (170 pag.)US2019/361345; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary