Month: August 2021

Adding a certain compound to certain chemical reactions, such as: 55289-36-6, name is 3-Bromo-2-methylaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55289-36-6, Recommanded Product: 55289-36-6

68A. 3-bromo-2-methylphenol To a solution of 3-bromo-2-methylaniline (6 g, 32.2 mmol) in sulfuric acid (38.7 mL, 38.7 mmol) at 0 C. was added slowly of a solution of sodium nitrite (2.67 g, 38.7 mmol). After stirring at 0 C. for 15 min, sulfuric acid (13.75 mL, 258 mmol) was added and the solution was heated at 100 C. for 1 h. The mixture was diluted with water, extracted with Et2O, dried and concentrated. Purification via silica gel chromatography gave 68A (light brown solid, 4.92 g, 82% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Bristol-Myers Squibb Company; US2011/82165; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 13633-25-5, A common heterocyclic compound, 13633-25-5, name is 1-Bromo-4-phenylbutane, molecular formula is C10H13Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3) 0.24 g (10 mmol) of sodium hydride and 15 ml of N, N-dimethylformamide were added to a 50 ml round bottom flask at room temperatureStir for 10 minutes,Then, 2.5 g (10 mmol) of compound 2 and 10 mmol of 1-bromo-4-phenylbutane were added and subjected to thin layer chromatography to the end of the reaction. The reaction solution was then poured into 500 ml of ice water, extracted three times with 100 ml of ethyl acetate,The organic phase was combined and the solvent was evaporated to dryness. The resulting residue was purified by silica gel column chromatography (V dichloromethane: V methanol = 100: 1) to give Compound 3 (3.1 g, yield 82%).

The synthetic route of 13633-25-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangxi Normal University; Chen Zhenfeng; Liang Hong; Liu Yancheng; Lu Xing; Li Liangping; (13 pag.)CN106478690; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 17247-58-4, name is (Bromomethyl)cyclobutane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17247-58-4, Product Details of 17247-58-4

Synthesis 9(f)Chemical Formula C16H17NO4 Chemical Formula C21H2JNO4 Chemical Formula C21H27NO4 Exact Mass 287 1 Exact Mass 355 2 Exact Mass 357 2 Molecular Weight 287 3 Molecular Weight 355 4 Molecular Weight 357 4Noroxymorphone N-(CBM)-Noroxymorphone Nalbuphine N-fcyclobutylmethy?-NoroxymorphoneStep 1: Synthesis of N-(cvclobutylmethyl)-Noroxymorphone from Noroxymorphone[0097] Noroxymorphone (1.59 g, 5.5 mmol), potassium carbonate (0.61 g, 6.1 mmol), potassium iodide (0.46 g, 2.8 mmol), and dimethyl acetamide (10 mL) were added into a round bottom flask. Bromomethylcyclobutane (0.82 g, 5.5 mmol, 0.62 mL) was added. The reaction was stirred for 7 days at room temperature. At that time, bromomethylcyclobutane (0.82 g, 5.5 mmol, 0.62 mL) was added. The reaction was stirred for an additional 7 days. HPLC analysis indicated that the noroxymorphone was consumed. Distilled water (50 mL) was added and stirred at room temperature for 6 hours. An off-white precipitate formed, which was removed by filtration. The solid was washed with distilled water (25 mL), then slurried for 24 hours in acetonitrile (25 mL). Filtration, washing the solid with acetonitrile (10 mL), and drying at room temperature under vacuum for 24 hours yielded N-(cyclobutylmethyl)-noroxymorphone (1.43 g, 73% yield) as a tan solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (Bromomethyl)cyclobutane, and friends who are interested can also refer to it.

Reference:
Patent; MALLINCKRODT INC.; WO2008/137672; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 65896-11-9, name is 2-Bromo-6-fluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2-Bromo-6-fluoroaniline

General procedure: To a solution of o-haloaniline (4.63 mmol) in dry DCM (20 mL) at room temperature was dropped acyl chloride (5.09 mmol). The reaction mixture was stirred for 24 hours then poured into water, extracted with DCM, washed with saturated NaHCO3, brine, dried over MgSO4, filtered and concentrated. The product was carried on to next step without any further purification in most cases.

According to the analysis of related databases, 65896-11-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Shi, Yajie; Zhou, Qifan; Du, Fangyu; Fu, Yang; Du, Yang; Fang, Ting; Chen, Guoliang; Tetrahedron Letters; vol. 60; 40; (2019);,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4549-33-1, name is 1,9-Dibromononane, A new synthetic method of this compound is introduced below., Recommanded Product: 4549-33-1

General procedure: To a stirred solution of monovalent beta-carbolines 1-17 (2.0 mmol) in anhydrous DMF (30 ml) was added 60% NaH (0.4 g, 10 mmol). After stirring for 20 min at room temperature, the appropriate dibromoalkane (1.0 mmol) was added. And then the reaction mixture was stirred at room temperature for 8-20 h. After completion of the reaction as indicated by TLC, the solution was poured into ice-water and extracted with CH2Cl2. The combined organic layer was washed with water and brine, dried over anhydrous Na2SO4, filtered and evaporated in vacuum. The residue was purified by column chromatography with CH2Cl2/MeOH (50:1) to successfully afford the desirable target products.

The synthetic route of 4549-33-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shi, Buxi; Cao, Rihui; Fan, Wenxi; Guo, Liang; Ma, Qin; Chen, Xuemei; Zhang, Guoxian; Qiu, Liqin; Song, Huacan; European Journal of Medicinal Chemistry; vol. 60; (2013); p. 10 – 22;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 43204-63-3, name is Bis(2-Bromoethyl)amine hydrobromide, A new synthetic method of this compound is introduced below., category: bromides-buliding-blocks

REFERENCE EXAMPLE 6 A mixture of di(2-bromoethyl)amine hydrobromide (15.6 g; 0.05 mol), 3-aminobenzotrifluoride (24.2 g; 0.15 mol) and methylethylketone (50 ml) was heated under reflux for 4 hours, and the resultant mixture was neutralized with a dilute sodium hydroxide solution and extracted with ether. The ethereal layer was washed with a saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was distilled to give N-(alpha, alpha, alpha-trifluorom-tolyl)piperazine. B.P., 130-140 C./0.3 mmHg.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Sumitomo Chemical Company, Limited; US4598078; (1986); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 937046-98-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 937046-98-5, name is 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 7-bromopyrrolo[2,1-f][1,2,4]triazin- 4-amine (250 mg, 1.174 mmol), (S)-1-tert-butyl 2-methyl 4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-1H-pyrrole-1,2(2H,5H)-dicarboxylate (912 mg, 2.58 mmol) and potassium phosphate tribasic (2 M in water) (1760 mul, 3.52 mmol) in DMF (6593 mul) was sparged with nitrogen for 5 min. PdCl2(dppf)-CH2Cl2 adduct (96 mg, 0.117 mmol) was added to the reaction mixture which was sparged with nitrogen for an additional 5 min. The mixture was brought to 100 C and stirred for 30 min. The reaction mixture was then diluted with EtOAc, washed with water, brine, dried over MgSO4, filtered and concentrated in vacuo. Purification by flash chromatography (Silica, 40g, 40 – 70% EtOAc/Hexanes) gave (S)-1-tert-butyl 2-methyl 4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7- yl)-1H-pyrrole-1,2(2H,5H)-dicarboxylate (165 mg, 0.459 mmol, 39.1 % yield). (0757) MS ESI (m/z) 360.1 (M+H)

The synthetic route of 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WATTERSON, Scott Hunter; ANDAPPAN MURUGAIAH SUBBAIAH, Murugaiah; DZIERBA, Carolyn Diane; GONG, Hua; GUERNON, Jason M.; GUO, Junqing; HART, Amy C.; LUO, Guanglin; MACOR, John E.; PITTS, William J.; SHI, Jianliang; VENABLES, Brian Lee; WEIGELT, Carolyn A.; WU, Yong-Jin; ZHENG, Zhizhen Barbara; SIT, Sing-Yuen; CHEN, Jie; (810 pag.)WO2019/147782; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 73918-56-6, name is 2-(4-Bromophenyl)ethanamine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 73918-56-6

General procedure: To compound 5, 6 or 7 (1 equiv) and the appropriate alkylamine(1.3 equiv) in anhydrous DMF (10 mL/mmol) were added DIEA (3equiv) and PyBOP (1 equiv), and the reaction mixturewas stirred atroom temperature under argon. When the reaction was complete(2 h – 4 h), the solvents were removed under reduced pressure togive a residue that was taken up in CH2Cl2. The solution waswashed with saturated aqueous NaHCO3, then water. The organiclayer was dried over Na2SO4 and then evaporated in vacuo. Purificationby flash chromatography afforded the corresponding amidederivatives 8, 9 or 10 (yield: 40-76%).

According to the analysis of related databases, 73918-56-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Paoletti, Julie; Assairi, Liliane; Gelin, Muriel; Huteau, Valerie; Nahori, Marie-Anne; Dussurget, Olivier; Labesse, Gilles; Pochet, Sylvie; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 1041 – 1056;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, A new synthetic method of this compound is introduced below., HPLC of Formula: C12H6Br2O

To a round bottom flask triphenylen-2-ylboronic acid 8.4g, 2,8-dibromodibenzo[b,d]furan 10.0g dissolved in toluene 280 ml K2CO3(2M) 46 ml and Pd(PPh3)4 1.1g After putting the mixture was stirred under reflux. Check the reaction by TLC and the reaction was terminated after addition of water. After the organic layer was extracted with MC and the residue was filtered under reduced pressure, re-crystallized to give an intermediate I1-1 8.1g (56% yield).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Dongjin SemiChem Co. Pvt. Ltd.; Ham, Ho-Wan; Kim, Bong-Ki; Kim, Seong-Hun; Ahn, Hyun-Chul; Kim, Hee-Ju; Kim, Dong-Jun; Lee, Hyung-Jin; Lim, Dong-Hwan; Ahn, Ja-Eun; (42 pag.)KR2016/80090; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 2550-36-9, These common heterocyclic compound, 2550-36-9, name is (Bromomethyl)cyclohexane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A suspension of compound 33 (496 mg, 2.88 mmol), solid potassium hydroxide (182 mg, 3.24 mmol) and tetrabutyl ammonium bisulfate (11 mg, 0.29 mmol) in toluene (4 mL) was heated to 50 C and the reaction was conducted for 2 h with vigorous stirring. To the above reaction mixture bromomethyl cyclohexane (639 mg, 3.61 mmol) was added dropwise and the reaction mixture was heated to 80 C. After 2 h, the reaction was cooled to rt, diluted with ethyl acetate, washed with water, brine and dried over anhydrous Na2SO4. The organic layer was concentrated to yield the product 34 as a yellow oil which is a mixture of rotamers (720 mg, 2.68 mmol, 93%); 1H NMR (CDCl3) delta 0.84-1.07 (m, 2H), 1.08-1.32 (m, 4H), 1.44 and 1.50 (s, 9H), 1.57-1.77 (m, 5H), 1.80 and 1.86 (s, 3H), 2.03 and 2.06 (s, 3H), 3.31 (d, J = 8.00 Hz, 2H).

Statistics shows that (Bromomethyl)cyclohexane is playing an increasingly important role. we look forward to future research findings about 2550-36-9.

Reference:
Article; Purohit, Meena K.; Chakka, Sai Kumar; Scovell, Iain; Neschadim, Anton; Bello, Angelica M.; Salum, Norue; Katsman, Yulia; Bareau, Madeleine C.; Branch, Donald R.; Kotra, Lakshmi P.; Bioorganic and Medicinal Chemistry; vol. 22; 9; (2014); p. 2739 – 2752;,
Bromide – Wikipedia,
bromide – Wiktionary