Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C6H2Br2F2
1,4-dibromo-2,5-difluorobenzene (1.36 g, 5mmol), potassium carbonate (1.04 g, 7.5mmol), and palladium acetate (56 mg, 0.25mmol) were taken under argon atmosphere, and DMAc (15 mL) was added and suspended. Into this mixture, a pivalic-acid-toluene solution (1.0M, 1.5 mL, 1.5mmol) and a tri-cyclohexyl phosphine toluene solution (0.6M, 833 **L, 0.5mmol), 2-(2-methylpropyl) thiazole (2.1 mL, 15mmol) was added, and it agitated at 100 degrees C for 20 hours. The mixed solvent (2:1) of chloroform and hexane was added to the reaction mixture after ending reaction, and it filtered using alumina. Silica gel column chromatography (eluate: hexane/ethyl acetate) refined the rough product obtained by condensing a filtrate, and it obtained the target 5-(4-bromo-2,5-difluorophenyl)-2-(2-methylpropyl) thiazole as a brown oily matter (414 mg, 25%).
According to the analysis of related databases, 327-51-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TOSOH CORPORATION; SAGAMI CHEMICAL RESEARCH INSTITUTE; Aihara, Hidenori; kikuchi, Mai; Hachiya, Hitoshi; Watanabe, Makoto; (39 pag.)JP2017/66069; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary