Quality Control of 7-Chloro-4-(piperazin-1-yl)quinoline. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about N-Propargylated isatin-Mannich mono- and bis-adducts: Synthesis and preliminary analysis of in vitro activity against Tritrichomonas foetus.
Cu(I)Cl promoted synthesis of N-propargylated-isatin Mannich mono- and bis-adducts, e.g. I [R = H, Me, Cl, etc.] with an extension towards the synthesis of N-propargylated-isatin-7-chloroquinoline conjugates was described. The synthesized scaffolds were evaluated for their in vitro activity against the veterinary protozoal pathogen Tritrichomonas fetus and cytotoxicity against human prostate cancer cell line. The preliminary evaluation data revealed the enhancement in the activity profiles with the introduction of 7-chloroquinoline ring with the most active conjugates I [R = H, Cl, Me] exhibiting IC50 of 22.2, 11.3 and 24.5 μM resp. against T. fetus and minimal toxicity against human prostate cell lines.
There is still a lot of research devoted to this compound(SMILES：C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3)Quality Control of 7-Chloro-4-(piperazin-1-yl)quinoline, and with the development of science, more effects of this compound(837-52-5) can be discovered.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary