Karageorgis, George; Reckzeh, Elena S.; Ceballos, Javier; Schwalfenberg, Melanie; Sievers, Sonja; Ostermann, Claude; Pahl, Axel; Ziegler, Slava; Waldmann, Herbert published an article about the compound: (S)-3,3′-Dibromo-1,1′-bi-2-naphthol( cas:119707-74-3,SMILESS:OC1=C(Br)C=C2C=CC=CC2=C1C3=C4C=CC=CC4=CC(Br)=C3O ).Reference of (S)-3,3′-Dibromo-1,1′-bi-2-naphthol. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:119707-74-3) through the article.
The principles guiding the design and synthesis of bioactive compounds based on natural product (NP) structure, such as biol.-oriented synthesis (BIOS), are limited by their partial coverage of the NP-like chem. space of existing NPs and retainment of bioactivity in the corresponding compound collections. Here the authors propose and validate a concept to overcome these limitations by de novo combination of NP-derived fragments to structurally unprecedented ‘pseudo natural products’. Pseudo NPs inherit characteristic elements of NP structure yet enable the efficient exploration of areas of chem. space not covered by NP-derived chemotypes, and may possess novel bioactivities. The authors provide a proof of principle by designing, synthesizing and studying the biol. properties of chromopynone pseudo NPs that combine biosynthetically unrelated chromane- and tetrahydropyrimidinone NP fragments. Chromopynones define a glucose uptake inhibitor chemotype that selectively targets glucose transporters GLUT-1 and -3, inhibits cancer cell growth and promises to inspire new drug discovery programs aimed at tumor metabolism
There is still a lot of research devoted to this compound(SMILES：OC1=C(Br)C=C2C=CC=CC2=C1C3=C4C=CC=CC4=CC(Br)=C3O)Reference of (S)-3,3′-Dibromo-1,1′-bi-2-naphthol, and with the development of science, more effects of this compound(119707-74-3) can be discovered.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary