COA of Formula: C13H14ClN3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about An efficient, green chemical synthesis of the malaria drug, piperaquine.
An efficient, robust green chem. synthesis of the malaria drug piperaquine in 92-93% overall yield via nucleophilic substitution reaction of dichloroquinoline and piperazine for potential use in resource-poor settings are described. The piperaquine was obtained in the correct salt form and sufficient purity for use in Artemisinin Combination Therapies. The overall process utilizes modest amounts (about 8 kg/kg) of 2-propanol and Et acetate as the only organic materials not incorporated into the API; roughly 60 % of this waste can be recycled into the production process. The synthesis may be useful for application in resource-poor settings as a means of expanding access to and reducing the cost of ACTs.
There is still a lot of research devoted to this compound(SMILES：C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3)COA of Formula: C13H14ClN3, and with the development of science, more effects of this compound(837-52-5) can be discovered.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary