So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lautens, Mark; Hiebert, Sheldon; Renaud, Jean-Luc researched the compound: (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene( cas:291536-01-1 ).Safety of (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene.They published the article 《Enantioselective Ring Opening of Aza and Oxabicyclic Alkenes with Dimethylzinc》 about this compound( cas:291536-01-1 ) in Organic Letters. Keywords: azabenzonorbornadiene methyl zinc stereoselective alkylative ring opening; oxabicyclic alkene methyl zinc stereoselective ring opening; alkylative ring opening catalyst palladium chiral phosphinooxazoline ligand; hydronaphthalene methyl stereoselective preparation; methylcyclohexenol stereoselective preparation; methylcycloheptenol stereoselective preparation. We’ll tell you more about this compound (cas:291536-01-1).
A system for efficient, asym. alkylative ring opening of azabenzonorbornadienes and [2.2.1] and [3.2.1] oxabicyclic alkenes was developed. The use of Pd(CH3CN)2Cl2 and chiral phosphinooxazoline ligands gave the corresponding dihydronaphthalenes, cyclohexenols, and cycloheptenols in excellent yields and enantiomeric excesses.
This literature about this compound(291536-01-1)Safety of (2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocenehas given us a lot of inspiration, and I hope that the research on this compound((2S)-1-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]-2-(diphenylphosphino)ferrocene) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary