COA of Formula: C13H14ClN3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Synthesis of oxalamide and triazine derivatives as a novel class of hybrid 4-aminoquinoline with potent antiplasmodial activity. Author is Sunduru, Naresh; Sharma, Moni; Srivastava, Kumkum; Rajakumar, S.; Puri, S. K.; Saxena, J. K.; Chauhan, Prem M. S..
Frequency of malaria and its resistance to chemotherapeutic options are emerging rapidly. To counter this problem, a series of 4-aminoquinolines having oxalamide and triazine functionalities in the side chain were synthesized and screened for their antimalarial activities. Triazine derivative 48 (I) found to be the most active against CQ sensitive strain 3D7 of Plasmodium falciparum in an in vitro assay with an IC50 of 5.23 ng/mL and oxalamide derivative 13 showed an in vivo suppression of 70.45% on day 4 against CQ resistant strain N-67 of Plasmodium yoelii.
This literature about this compound(837-52-5)COA of Formula: C13H14ClN3has given us a lot of inspiration, and I hope that the research on this compound(7-Chloro-4-(piperazin-1-yl)quinoline) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary