So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ananthan, Subramaniam; Saini, Surendra K.; Zhou, Guangyan; Hobrath, Judith V.; Padmalayam, Indira; Zhai, Ling; Bostwick, J. Robert; Antonio, Tamara; Reith, Maarten E. A.; McDowell, Shea; Cho, Eunie; McAleer, Leah; Taylor, Michelle; Luedtke, Robert R. researched the compound: 7-Chloro-4-(piperazin-1-yl)quinoline( cas:837-52-5 ).SDS of cas: 837-52-5.They published the article 《Design, Synthesis, and Structure-Activity Relationship Studies of a Series of [4-(4-Carboxamidobutyl)]-1-arylpiperazines: Insights into Structural Features Contributing to Dopamine D3 versus D2 Receptor Subtype Selectivity》 about this compound( cas:837-52-5 ) in Journal of Medicinal Chemistry. Keywords: aroylaminobutyl arylpiperazine preparation selective dopamine D3 receptor ligand; structure aroylaminobutyl arylpiperazine antagonism partial agonism dopamine D3 receptor; selectivity aroylaminobutyl arylpiperazine binding D3 D2 dopamine receptor; mol docking calculation aroylaminobutyl arylpiperazine bound dopamine D3 receptor; calculated lipophilicity aroylaminobutyl arylpiperazine. We’ll tell you more about this compound (cas:837-52-5).
(Aroylaminobutyl)arylpiperazines such as I were prepared as antagonists or partial agonists of the dopamine D3 receptor selective for D3 receptors over the related dopamine D2 receptors for potential use in treatment of drug addiction and schizophrenia. The calculated lipophilicities of and inhibition of dopamine D3 and D2 receptors by (aroylaminobutyl)arylpiperazines was determined, and the inhibition of mutant and chimeric D3 receptors by selected compounds and the activities of selected compounds in functional assays in human cells were determined Mol. docking calculations of the structures of selected compounds bound to dopamine D3 receptors were performed; the mol. docking studies and evaluation against a set of chimeric and mutant receptors suggest that interactions at the extracellular end of TM7 contribute to the selectivity of the ligands for dopamine D3 receptors over dopamine D2 receptors.
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Reference:
Bromide – Wikipedia,
bromide – Wiktionary