Safety of 7-Chloro-4-(piperazin-1-yl)quinoline. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity. Author is Pepe, Dionissia A.; Toumpa, Dimitra; Andre-Barres, Christiane; Menendez, Christophe; Mouray, Elisabeth; Baltas, Michel; Grellier, Philippe; Papaioannou, Dionissios; Athanassopoulos, Constantinos M..
A series of novel hybrids of artemisinin (ART) with either a phytormone endoperoxide G factor analog (GMeP) or chloroquine (CQ) and conjugates of the same compounds with the polyamines (PAs), spermidine (Spd), and homospermidine (Hsd) were synthesized and their antiplasmodial activity was evaluated using the CQ-resistant P. falciparum FcB1/Colombia strain. The ART-GMeP hybrid I and compounds II [n = 1, 2] which are conjugates of Spd and Hsd with two mols. of ART and one mol. of GMeP, were the most potent with IC50 values of 2.6, 8.4, and 10.6 nM, resp. The same compounds also presented the highest selectivity indexes against the primary human fibroblast cell line AB943 ranging from 16,372 for the hybrid I to 983 for the conjugate II [n = 2] of Hsd.
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Reference:
Bromide – Wikipedia,
bromide – Wiktionary