So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hinklin, Ronald J.; Baer, Brian R.; Boyd, Steven A.; Chicarelli, Mark D.; Condroski, Kevin R.; DeWolf, Walter E. Jr.; Fischer, John; Frank, Michele; Hingorani, Gary P.; Lee, Patrice A.; Neitzel, Nickolas A.; Pratt, Scott A.; Singh, Ajay; Sullivan, Francis X.; Turner, Timothy; Voegtli, Walter C.; Wallace, Eli M.; Williams, Lance; Aicher, Thomas D. researched the compound: 4,4-Dipyridyl Disulfide( cas:2645-22-9 ).Application of 2645-22-9.They published the article 《Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator》 about this compound( cas:2645-22-9 ) in Bioorganic & Medicinal Chemistry. Keywords: hiadiazole heteroaryloxypyridine AR453588 synthesis antidiabetic SAR glucokinase activator diabetes; Diabetes; Glucokinase; Glucokinase activator; OGTT; S(0.5); Structure-aided design; Structure-based design; Type II diabetes; V(max); ob/ob mouse. We’ll tell you more about this compound (cas:2645-22-9).
Glucose flux through glucokinase (GK) controls insulin release from the pancreas in response to high levels of glucose. Flux through GK is also responsible for reducing hepatic glucose output. Since many individuals with type 2 diabetes appear to have an inadequacy or defect in one or both of these processes, identifying compounds that can activate GK could provide a therapeutic benefit. Herein we report the further structure activity studies of a novel series of glucokinase activators (GKA). These studies led to the identification of pyridine 72 as a potent GKA that lowered post-prandial glucose in normal C57BL/6J mice, and after 14d dosing in ob/ob mice. 3-(heteroaryloxy)pyridine.
This literature about this compound(2645-22-9)Application of 2645-22-9has given us a lot of inspiration, and I hope that the research on this compound(4,4-Dipyridyl Disulfide) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary