Product Details of 837-52-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Synthesis, antimalarial activity evaluation and docking studies of some novel tetraoxaquines. Author is Kumawat, Mukesh Kumar; Parida, Pratap; Chetia, Dipak.
Tetraoxaquines, mol. hybrids of 1,2,4,5-tetraoxane and 4-aminoquinoline, were designed via mol. docking anal. against Falcipain-2. Among the studied compounds, 11 top scoring analogs showing low binding energy were further selected for synthesis and evaluated for their in vitro antimalarial activity. In inhibitory assay, five compounds showed significant activity against chloroquine-resistant strain of P. falciparum-RKL-9 with IC50 values of 3.906, 3.942, 4.272, 3.906, 4.814 μg/mL.
After consulting a lot of data, we found that this compound(837-52-5)Product Details of 837-52-5 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Bromide – Wikipedia,
bromide – Wiktionary